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Bifidobacterium, BB-12®

- the world’s most documented probiotic Bifidobacterium

BB-12 probiotic strain for babies
Chr. Hansen strains BB-12®
6 Min read

Bifidobacterium, BB-12® (hereafter referred to by the trademark BB-12®) has been extensively studied and published in scientific publications. It has been used worldwide since 1986 with no safety concerns. BB-12® has been associated with supporting the immune system and the digestive health of children and adults (alone, and in combination with other probiotic strains).

Fact

Bifidobacterium, BB-12® has been scientifically studied and associated with digestive and immune system support.

Chr. Hansen’s Bifidobacterium, BB-12®

Bifidobacteria were discovered and isolated from the stool sample of a breastfed baby in 1899.1 The Chr. Hansen Bifidobacterium, BB-12® originates from our collection of dairy cultures and is used in baby formula, dietary supplements, and fermented milk products (such as yogurt) worldwide.
The BB-12® strain has been described in more than 300 scientific publications, making the BB-12® strain the world’s most documented probiotic Bifidobacterium. More than 200 of these publications are from human scientific studies that investigated the impact of BB-12® across various areas of health, ranging from preterm and newborn babies to the elderly.

 
The world's most documented
Bifidobacterium
More than
clinical study
publications
Fact

The World Health Organisation (WHO) recommends breastfeeding exclusively for the first six months, followed by continued breastfeeding together with complementary foods.2

Happy healthy baby BB-12 probiotic strain

Bifidobacterium, BB-12® has been associated with numerous health benefits

In babies and children:


Digestive health

Associated with softer and more frequent bowel movements,3 and shorter and fewer episodes of loose stools.4,5

Excessive crying and fussing*

Associated with significantly less excessive crying and fussing in babies.6

Respiratory health

Associated with fewer episodes of respiratory discomfort.7, 8, 9

Immune health

Associated with greater immune system support.10

Skin health*

Associated with fewer instances of red, dry, and scaly skin in babies.11

In adults:

 
Oral health*

Associated with lower salivary levels of specific bacteria that contribute to poor oral health.12

Frequency of bowel movements

Associated with more regular bowel movements in adults13, 14 and the elderly.15 

Immune health*

Associated with benefits for immune system function.16

Cholesterol levels#

Associated with supporting healthy levels of cholesterol.17

 
* studied alone, # studied in combination with other strains, studied alone and in combination with other strains
Scientist analyzing the BB-12 probiotic strain

Safety

BB-12® is safe for human consumption; it has been granted QPS18 (Qualified Presumption of Safety) status in Europe and has been the subject of a GRAS (Generally Recognized as Safe) notice to the US Food And Drug Administration.19 It has been tested in human scientific studies at levels up to at least 100 billion CFU/day (colony forming units), with no safety issues.


BB-12® is a registered trademark of Chr. Hansen A/S 

The article is provided for informational purposes regarding probiotics and is not meant to suggest that any substance referenced in the article is intended to diagnose, cure, mitigate, treat, or prevent any disease.

 
Our Chr. Hansen probiotic strains

At Chr. Hansen, our strains are backed by science. All of our probiotic strains are supported by clinical documentation. Learn more about the beneficial effects our strains have on different health areas.

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Reference list

1. Jungersen, et al. Microorganisms. 2014;2:92-110. (PubMed)

2. World Health Organisation. Accessed September 20, 2021. (Source

3.  Vlieger AM, et al. Br J Nutr. 2009;102(6):869-75. (PubMed)

4.  Weizman Z, et al. Pediatrics. 2005;115(1):5-9. (PubMed)

5. Saavedra JM, et al. Lancet. 1994;344(8929):1046-9. (PubMed)

6.  Nocerino R, et al. Aliment Pharmacol Ther. 2019. (PubMed)

7.  Taipale TJ, et al. Br J Nutr. 2011;105(3):409-16. (PubMed)

8.  Taipale TJ, et al. Pediatr Res. 2016;79(1-1):65-9. (PubMed)

9.  Rautava S, et al. Br J Nutr. 2009;101(11):1722-6. (PubMed)

10.  Holscher HD, et al. J Parenter Enteral Nutr. 2012;36(1 Suppl):106s-17s. (PubMed)

11.  Isolauri E, et al. Clin Exp Allergy. 2000;30(11):1604-10. (PubMed)

12. Caglar E, et al. Acta Odontol Scand. 2008;66(3):154-8. (PubMed)

13. Eskesen D, et al. Br J Nutr. 2015;114(10):1638-46. (PubMed)

14.  Uchida K, et al. Journal of Nutritional Food. 2005;8:39-51. Artikel kan ikke findes i PubMed

15.  Pitkala KH, et al. J Nutr Health Aging. 2007;11(4):305-11. (PubMed)

16. Rizzardini G, et al. Br J Nutr. 2012;107(6):876-84. (PubMed)

17. Ejtahed HS, et al. J Dairy Sci. 2011;94(7):3288-94. (PubMed)

18. EFSA Panel on Biological Hazards (BIOHAZ). EFSA Journal. 2015;13:4331.

19. Food and Drug Administration. GRAS Notice Inventory > Agency Response Letter GRAS Notice No GRN 000049. 2002.

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